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Central obesity is selectively associated with cerebral gray matter atrophy in 15,634 subjects in the UK Biobank

Medicine and Health

Central obesity is selectively associated with cerebral gray matter atrophy in 15,634 subjects in the UK Biobank

C. Pflanz, D. J. Tozer, et al.

This study, conducted by Chris-Patrick Pflanz and colleagues, reveals a fascinating link between central obesity and reductions in brain gray matter volume, particularly affecting key subcortical structures. Discover how body fat distribution can influence brain health in over 15,000 participants from the UK Biobank.

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Playback language: English
Abstract
This study investigated the association between obesity and brain gray matter (GM) volume in 15,634 participants from the UK Biobank. Central obesity, assessed using various methods (anthropometric data, DXA, abdominal MRI), was significantly associated with decreased GM volume, particularly in subcortical nuclei (thalamus, caudate, pallidum, nucleus accumbens). No associations were found with white matter (WM) volume, brain network efficiency, or mediation by cardiovascular risk factors. The findings suggest that central body fat distribution is linked to GM changes in obese individuals.
Publisher
International Journal of Obesity
Published On
Feb 10, 2022
Authors
Chris-Patrick Pflanz, Daniel J. Tozer, Eric L. Harshfield, Jonathan Tay, Sadaf Farooqi, Hugh S. Markus
Tags
obesity
brain gray matter
central obesity
UK Biobank
subcortical nuclei
fat distribution
neuroscience

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