Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription

This study investigated the molecular mechanisms associated with chronic caffeine consumption in the mouse hippocampus using untargeted orthogonal omics techniques. Chronic caffeine exerted pleiotropic effects on the hippocampus at the epigenomic, proteomic, and metabolomic levels. Caffeine lowered metabolism-related processes in bulk tissue, but induced neuron-specific epigenetic changes at synaptic transmission/plasticity-related genes and increased experience-driven transcriptional activity. These findings suggest that regular caffeine intake improves signal-to-noise ratio during information encoding and boosts information processing during learning.

Isabel Paiva, Lucrezia Cellai, Céline Meriaux, Lauranne Poncelet, Ouada Nebie, Jean-Michel Saliou, Anne-Sophie Lacoste, Emilie Faivre, Kevin Carvalho, Hervé Drobecq, Stéphanie Le Gras, Marion Schneider, Enas M. Malik, Christa E. Müller, Anthony Papegaey, Victoria Gomez-Murcia, Didier Vieau, Bryan Thiroux, Sabiha Eddarkaoui, Thibaud Lebouvier, Estelle Schueller, Laura Tzeplaeff, Iris Grgurina, Jonathan Seguin, Nicolas Sergeant, Jean-Sébastien Annicotte, Anne-Laurence Boutillier, David Blum