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C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

Medicine and Health

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

B. F. Vahsen, S. Nalluru, et al.

This groundbreaking research conducted by Björn F. Vahsen and colleagues uncovers the toxic effects of *C9orf72* hexanucleotide repeat expansions in microglia, revealing their deleterious impact on motor neurons through MMP9 signaling. Discover how this cellular dysfunction contributes to the pathophysiology of ALS.... show more
Citation Metrics
Citations
70
Influential Citations
5
Reference Count
44
Citation by Year

Note: The citation metrics presented here have been sourced from Semantic Scholar and OpenAlex.

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