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C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

Medicine and Health

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

B. F. Vahsen, S. Nalluru, et al.

This groundbreaking research conducted by Björn F. Vahsen and colleagues uncovers the toxic effects of *C9orf72* hexanucleotide repeat expansions in microglia, revealing their deleterious impact on motor neurons through MMP9 signaling. Discover how this cellular dysfunction contributes to the pathophysiology of ALS.

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