Biology

Broadly neutralizing antibodies against COVID-19

D. Zhou, J. Ren, et al.

Explore the cutting-edge research by Daming Zhou and colleagues on the challenges posed by SARS-CoV-2 mutations and the promise of broadly neutralizing monoclonal antibodies to maintain therapeutic efficacy. Discover how these innovative treatments can play a crucial role in combating COVID-19 variants.

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Playback language: English

Index

Abstract

The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in millions of infections and deaths. Human monoclonal antibodies (mAbs) offer an effective treatment option. However, the virus's rapid mutation leads to immune escape from most neutralizing mAbs, including approved therapeutics. This review focuses on four types of broadly neutralizing mAbs targeting the spike protein: those targeting the receptor-binding domain (RBD), subdomain 1 (SD1), stem helix, or fusion peptide. Understanding how these mAbs maintain potency against various variants is crucial for developing future therapeutics and vaccines.

Publisher

Current Opinion in Virology

Published On

Apr 26, 2023

Authors

Daming Zhou, Jingshan Ren, Elizabeth E Fry, David I Stuart, Kuan-Ying Arthur Huang, Chealex Ma

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