This study presents an interactive open-access resource ("brain charts") to benchmark brain morphology derived from MRI data across the human lifespan. Aggregating 123,984 MRI scans from over 100 studies, the researchers generated normative trajectories for multiple brain structures, identifying previously unreported neurodevelopmental milestones. Centile scores, derived from these trajectories, showed increased heritability and revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. Brain charts provide a crucial step towards robust quantification of individual brain variation.

Author 1, Author 2