Medicine and Health

Brain charts for the human lifespan

A. 1 and A. 2

This groundbreaking research conducted by Author 1 and Author 2 introduces 'brain charts,' an interactive open-access resource utilizing MRI data to benchmark brain morphology throughout the human lifespan. By analyzing 123,984 MRI scans, the study reveals new neurodevelopmental milestones and insights into brain variation across various neurological and psychiatric disorders.

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Index

Abstract

This study presents an interactive open-access resource ("brain charts") to benchmark brain morphology derived from MRI data across the human lifespan. Aggregating 123,984 MRI scans from over 100 studies, the researchers generated normative trajectories for multiple brain structures, identifying previously unreported neurodevelopmental milestones. Centile scores, derived from these trajectories, showed increased heritability and revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. Brain charts provide a crucial step towards robust quantification of individual brain variation.

Publisher

Nature

Published On

Apr 21, 2022

Authors

Author 1, Author 2

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