Medicine and Health

Behavior of glioblastoma brain tumor stem cells following a suborbital rocket flight: reaching the "edge" of outer space

C. A. Garcia, P. Suárez-meade, et al.

This groundbreaking research by Cesar A. Garcia and colleagues uncovers the surprising effects of suborbital rocket flights on glioblastoma brain tumor initiating cells (BTICs). The findings reveal that exposure to altered gravity can lead to increased migration and aggressiveness of BTICs, suggesting profound implications for cancer treatment.

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Index

Abstract

This study investigated the effects of a suborbital rocket flight on glioblastoma brain tumor initiating cells (BTICs). Patient-derived QNS108 BTICs were exposed to altered gravity conditions during the flight. Post-flight, in vitro and in vivo assays revealed that rocket-flight exposed cells exhibited significantly increased migration and stemness, along with larger tumor-associated cystic growth areas and decreased survival in mice compared to ground controls. These findings suggest that even brief exposure to altered gravity conditions can induce lasting changes in BTICs, leading to a more aggressive phenotype.

Publisher

npj Microgravity

Published On

Dec 18, 2023

Authors

Cesar A. Garcia, Paola Suárez-Meade, Mieu Brooks, Adip G. Bhargav, Michelle L. Freeman, Lawrence M. Harvey, John Quinn, Alfredo Quiñones-Hinojosa

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