Medicine and Health

Barbed arrow-like structure membrane with ultra-high rectification coefficient enables ultra-fast, highly-sensitive lateral-flow assay of cTnI

J. Li, Y. Liu, et al.

Discover a groundbreaking advancement in cardiac troponin I detection with the introduction of the barbed arrow-like structure membrane (BAS Mem). This innovative approach enables incredibly fast and sensitive lateral-flow assays, achieving results in just 240 seconds. Researchers Juanhua Li, Yiren Liu, Tianyu Wu, Zihan Xiao, Jianhang Du, Hongrui Liang, Cuiping Zhou, and Jianhua Zhou have pioneered a technique that promises to enhance timely diagnosis of acute myocardial infarction.

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Abstract

This paper introduces a novel barbed arrow-like structure membrane (BAS Mem) for lateral-flow assays (LFAs) of cardiac troponin I (cTnI), a key biomarker for acute myocardial infarction (AMI). The BAS Mem's unique structure enables unidirectional, fast liquid flow with an unprecedented rectification coefficient of 14.5. LFAs using BAS Mem achieve cTnI detection within 240 seconds, with a limit of detection of 1.97 ng mL⁻¹ and high sensitivity (93.3%) and specificity (100%) in clinical samples. This ultra-fast and highly sensitive assay shows great promise for timely AMI diagnosis.

Publisher

Nature Communications

Published On

Jul 03, 2024

Authors

Juanhua Li, Yiren Liu, Tianyu Wu, Zihan Xiao, Jianhang Du, Hongrui Liang, Cuiping Zhou, Jianhua Zhou

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