This study investigated the potential of spice-based antimycotics to control Candida albicans biofilms. Two high biofilm-forming C. albicans isolates (M-207 and S-470) resistant to fluconazole and caspofungin were selected. Aqueous spice extracts were screened for antimycotic activity. Garlic extract effectively inhibited M-207 biofilms, while garlic, clove, and Indian gooseberry extracts controlled S-470 biofilms. Allicin, ellagic acid, and gallic acid were identified as dominant compounds in the respective extracts. Microscopic analyses revealed changes in biofilm morphology following treatment. The study suggests that aqueous extracts of garlic, clove, and Indian gooseberry offer a safe, potential, and cost-effective alternative for controlling drug-resistant C. albicans biofilms.
