Biology

Aqueous spice extracts as alternative antimycotics to control highly drug-resistant extensive biofilm-forming clinical isolates of Candida albicans

B. Sadanandan, V. Vijayalakshmi, et al.

Discover groundbreaking research on spice-based antimycotics by Bindu Sadanandan and colleagues, revealing the impressive ability of garlic, clove, and Indian gooseberry extracts to combat drug-resistant Candida albicans biofilms, offering a safe and cost-effective alternative to conventional treatments.

00:00

Playback language: English

Index

Abstract

This study investigated the potential of spice-based antimycotics to control Candida albicans biofilms. Two high biofilm-forming C. albicans isolates (M-207 and S-470) resistant to fluconazole and caspofungin were selected. Aqueous spice extracts were screened for antimycotic activity. Garlic extract effectively inhibited M-207 biofilms, while garlic, clove, and Indian gooseberry extracts controlled S-470 biofilms. Allicin, ellagic acid, and gallic acid were identified as dominant compounds in the respective extracts. Microscopic analyses revealed changes in biofilm morphology following treatment. The study suggests that aqueous extracts of garlic, clove, and Indian gooseberry offer a safe, potential, and cost-effective alternative for controlling drug-resistant C. albicans biofilms.

Publisher

PLOS ONE

Published On

Jun 14, 2023

Authors

Bindu Sadanandan, Vaniyamparambath Vijayalakshmi, Priya Ashrit, Uddagiri Venkanna Babu, Lakavalli Mohan, Sharath Kumar, Vasulingam Sampath, Kalidas Shetty, Amruta Purushottam Joglekar, Rashmi Awaknavar

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

Highly drug resistant clone of *Salmonella* Kentucky ST198 in clinical infections and poultry in Zimbabwe

T. Mashe, G. Thilliez, et al.

Medicine and Health

Rule-based omics mining reveals antimicrobial macrocyclic peptides against drug-resistant clinical isolates

Z. Cheng, B. He, et al.

Medicine and Health

Gastric emptying of a glucose drink is predictive of the glycaemic response to oral glucose and mixed meals, but unrelated to antecedent glycaemic control, in type 2 diabetes

C. Xiang, Y. Sun, et al.

Medicine and Health

Pulmonary expansion manoeuvres compared to usual care on ventilatory mechanics, oxygenation, length of mechanical ventilation and hospital stay, extubation, atelectasis, and mortality of patients in mechanical ventilation: A randomized clinical trial

K. D. Silva, C. Cristino, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny