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Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania

Medicine and Health

Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania

M. Gardea-resendez, B. J. Coombes, et al.

This groundbreaking study explores how antidepressants may impact mitochondrial function differently and their association with treatment-emergent mania in bipolar disorder. Conducted by a team of researchers led by Manuel Gardea-Resendez, the findings suggest a novel approach to reclassifying antidepressants for better risk assessment.

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Playback language: English
Abstract
Preclinical evidence suggests antidepressants (ADs) may differentially affect mitochondrial energetics. This study investigated the relationship between mitochondrial function and bipolar disorder (BD) illness vulnerability, specifically treatment-emergent mania (TEM+). Participants with BD (TEM+ n=176, TEM- n=516) were classified based on whether their associated AD increased (Mito+; n=600) or decreased (Mito–; n=289) mitochondrial electron transport chain (ETC) activity. Generalized estimating equations, adjusted for sex, age, and BD type, revealed TEM+ was more frequent with Mito+ ADs (24.7%) than Mito– ADs (13.5%) (OR = 2.21; p = 0.000009). These findings suggest reclassifying ADs based on mitochondrial energetics, in addition to monoaminergic mechanisms, for improved risk assessment of TEM+.
Publisher
Molecular Psychiatry
Published On
Authors
Manuel Gardea-Resendez, Brandon J. Coombes, Marin Velidic, Susannah J. Tye, Francisco Romo-Nava, Asygul Ozeroglu, Miguel L. Prieto, Alfredo Cuellar-Barboza, Nicolas A. Nunez, Balwinder Singh, Richard S. Pendergraft, Alessandro Miola, Susan L. McElroy, Joanna M. Biernacka, Eva Morava, Tamas Koczi, Mark A. Frye
Tags
antidepressants
mitochondrial function
bipolar disorder
treatment-emergent mania
risk assessment
electron transport chain

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