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Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4

Medicine and Health

Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4

X. Zhou, S. Kong, et al.

Discover the groundbreaking research conducted by Xin Zhou, Sophie Kong, and colleagues on protein arginine deiminase 4 (PAD4), uncovering its role in rheumatoid arthritis. This study reveals how functional antibodies can activate or inhibit PAD4 activity through allosteric modulation, providing new insights into enzyme regulation that could pave the way for innovative treatment approaches.

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