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Analyses of canine cancer mutations and treatment outcomes using real-world clinico-genomics data of 2119 dogs

Veterinary Science

Analyses of canine cancer mutations and treatment outcomes using real-world clinico-genomics data of 2119 dogs

K. Wu, L. Rodrigues, et al.

This groundbreaking study by Kevin Wu and colleagues examines the striking parallels between canine and human cancers, unveiling key oncogenes and their potential in personalized oncology. With data from over 2,100 dogs, the research showcases how targeted treatments for humans may offer promising insights for canine models, paving the way for innovative drug discovery.

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Playback language: English
Abstract
Canine spontaneous tumors offer valuable insights into human cancers due to shared genetic and histological similarities. This study analyzed clinico-genomic data from 2119 dogs with tumors, identifying prognostic concordance between canine and human cancers for key oncogenes like *TP53* and *PIK3CA*. The analysis also revealed that several human-designed targeted treatments showed positive prognostic associations with specific canine genomic alterations, highlighting the potential of canine models for personalized oncology drug discovery.
Publisher
npj Precision Oncology
Published On
Jan 19, 2023
Authors
Kevin Wu, Lucas Rodrigues, Gerald Post, Garrett Harvey, Michelle White, Aubrey Miller, Lindsay Lambert, Benjamin Lewis, Christina Lopes, James Zou
Tags
canine cancers
human cancers
oncogenes
TP53
PIK3CA
genomic alterations
personalized oncology

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