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Abstract
Canine spontaneous tumors offer valuable insights into human cancers due to shared genetic and histological similarities. This study analyzed clinico-genomic data from 2119 dogs with tumors, identifying prognostic concordance between canine and human cancers for key oncogenes like *TP53* and *PIK3CA*. The analysis also revealed that several human-designed targeted treatments showed positive prognostic associations with specific canine genomic alterations, highlighting the potential of canine models for personalized oncology drug discovery.
Publisher
npj Precision Oncology
Published On
Jan 19, 2023
Authors
Kevin Wu, Lucas Rodrigues, Gerald Post, Garrett Harvey, Michelle White, Aubrey Miller, Lindsay Lambert, Benjamin Lewis, Christina Lopes, James Zou
Tags
canine cancers
human cancers
oncogenes
TP53
PIK3CA
genomic alterations
personalized oncology

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