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An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping

Medicine and Health

An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping

S. Hamada, M. Nagase, et al.

This groundbreaking research by Shun Hamada and colleagues unveils a novel ChR2 variant engineered to target presynaptic axon terminals, enhancing optogenetic manipulation of neural circuits. The innovative mGluR2-PA tag significantly improves accuracy in circuit mapping, enabling effective transmitter release with minimal photostimulation. Discover how this advancement could transform neural circuit research!

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~3 min • Beginner • English
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