Biology

An economic demand-based framework for prioritization strategies in response to transient amino acid limitations

R. Gupta, S. Adhikary, et al.

This fascinating study conducted by Ritu Gupta, Swagata Adhikary, Nidhi Dalpatraj, and Sunil Laxman explores how yeast cells intelligently restore essential amino acids when their supply is disrupted. The researchers quantified the costs and demands of amino acid biosynthesis, revealing that metabolic priorities lead to a remarkable restoration response, particularly for arginine. Discover the implications for metabolic engineering and amino acid responses in this compelling research!

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Index

Abstract

This study investigates how yeast cells prioritize the restoration of distinct amino acids after disrupting their supply. Researchers quantified amino acid biosynthetic supply costs and total demand, revealing that restoration priority is driven by high demand coupled with low supply costs. Metabolic requirements dominate demand, with the largest restoration response observed for arginine. This demand-driven framework offers insights into amino acid responses and potential metabolic engineering applications.

Publisher

Nature Communications

Published On

Aug 23, 2024

Authors

Ritu Gupta, Swagata Adhikary, Nidhi Dalpatraj, Sunil Laxman

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