Medicine and Health

An ecological framework to understand the efficacy of fecal microbiota transplantation

Y. Xiao, M. T. Angulo, et al.

Discover an innovative ecological framework for understanding the impact of fecal microbiota transplantation (FMT) on gut health, particularly for recurrent Clostridioides difficile infections. This research, led by Yandong Xiao, Marco Tulio Angulo, Songyang Lao, Scott T. Weiss, and Yang-Yu Liu, provides a pathway for designing personalized probiotic therapies that could revolutionize treatment options.

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Abstract

Human gut microbiota plays critical roles in physiology and disease. This research presents an ecological framework to understand the efficacy of fecal microbiota transplantation (FMT) in treating conditions associated with a disrupted gut microbiota, using recurrent *Clostridioides difficile* infection as a prototype. The framework predicts key factors determining FMT efficacy and offers an algorithm for designing personalized probiotic cocktails. Preclinical mouse experiments and a clinical trial validate the framework, improving understanding of FMT's ecological principles and impacting the design of microbiota-based therapeutics.

Publisher

Nature Communications

Published On

Jul 03, 2020

Authors

Yandong Xiao, Marco Tulio Angulo, Songyang Lao, Scott T. Weiss, Yang-Yu Liu

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