Medicine and Health

An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease

P. Ghosh, G. D. Katkar, et al.

This compelling study reveals shared immunopathogenesis pathways between Multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD), highlighting an IL15/IL15RA-centric cytokine storm. Conducted by a team of experts including Pradipta Ghosh and Jane C. Burns, it identifies unique targetable pathways in MIS-C and suggests it is more severe than KD, providing critical insights for clinical monitoring.

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