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An ancestral SARS-CoV-2 vaccine induces anti-Omicron variants antibodies by hypermutation

Medicine and Health

An ancestral SARS-CoV-2 vaccine induces anti-Omicron variants antibodies by hypermutation

S. Park, J. Choi, et al.

This research conducted by Seoryeong Park, Jaewon Choi, and others explores how the Omicron variant-neutralizing antibodies evolve following booster vaccinations with the BNT162b2 vaccine. With an exciting discovery of somatic hypermutation leading to a broad immune response, the study reveals a potential protective mechanism against viral escape.

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Abstract
This study investigated the development of Omicron variant-neutralizing antibodies after repeated vaccination with the ancestral SARS-CoV-2 BNT162b2 vaccine. Analysis of blood samples from 41 vaccinees revealed that combinatorial reactivity to Omicron and its receptor-binding domain (RBD) was achieved through somatic hypermutation (SHM) accumulation after the third dose. A limited number of BCR clonotypes contributed to this broadened specificity, suggesting a counterprotective mechanism against viral immune escape.
Publisher
Nature Communications
Published On
Apr 20, 2024
Authors
Seoryeong Park, Jaewon Choi, Yonghee Lee, Jinsung Noh, Namphil Kim, JinAh Lee, Geummi Cho, Sujeong Kim, Duck Kyun Yoo, Chang Kyung Kang, Pyeong Gyun Cho, Nam Joong Kim, Wan Beom Park, Seungtake Kim, Myoung-ong Oh, Sunghoon Kwon, Junho Chung
Tags
Omicron variant
neutralizing antibodies
BNT162b2 vaccine
somatic hypermutation
viral immune escape
vaccination
BCR clonotypes

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