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Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis

Medicine and Health

Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis

D. N. Douda, L. Yip, et al.

Discover how the research conducted by David N. Douda, Lily Yip, Meraj A. Khan, Hartmut Grasemann, and Nades Palaniyar reveals the pivotal role of Akt in regulating the balance between neutrophil death through NETosis and apoptosis, shedding light on the inflammatory response in various diseases.

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Playback language: English
Abstract
Neutrophil extracellular traps (NETs) contribute to several diseases. This study investigates the role of Akt in regulating the switch between NETosis (pro-inflammatory) and apoptosis (anti-inflammatory) in neutrophils. The authors demonstrate that PMA activates Akt, which is dependent on NOX2-mediated ROS production. Using Akt inhibitors, they show that Akt is essential for NETosis, and its suppression switches neutrophil death from NETosis to apoptosis.
Publisher
Blood
Published On
Jan 23, 2014
Authors
David N. Douda, Lily Yip, Meraj A. Khan, Hartmut Grasemann, Nades Palaniyar
DOI
https://doi.org/10.1182/blood-2013-09-526707
Tags
NETosis
apoptosis
Akt
neutrophils
inflammation
ROS

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