This double-blind, randomized, placebo-controlled, crossover study investigated whether MDMA co-administration augments LSD's acute subjective effects. 24 healthy participants (12 women, 12 men) received placebo, 100 mg MDMA, 100 µg LSD, and the combination. MDMA did not alter the quality of LSD's acute subjective effects but prolonged their duration, correlating with higher LSD plasma concentrations and a longer half-life. The LSD + MDMA combination increased blood pressure, heart rate, and pupil size more than LSD alone, and both MDMA alone and the combination increased oxytocin levels more than LSD alone. Overall, MDMA co-administration did not improve LSD's acute effects or safety profile, suggesting limited benefit over LSD alone in psychedelic-assisted therapy.
Publisher
Neuropsychopharmacology
Published On
May 31, 2023
Authors
Isabelle Straumann, Laura Ley, Friederike Holze, Anna M. Becker, Aaron Klaiber, Kathrin Wey, Urs Duthaler, Nimmy Varghese, Anne Eckert, Matthias E. Liechti
Tags
MDMA
LSD
placebo-controlled
subjective effects
psychedelic-assisted therapy
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