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Active site remodelling of a cyclodipeptide synthase redefines substrate scope

Biology

Active site remodelling of a cyclodipeptide synthase redefines substrate scope

E. Sutherland, C. J. Harding, et al.

Discover how Emmajay Sutherland, Christopher John Harding, and Clarissa Melo Czekster have engineered cyclodipeptide synthases to produce valuable histidine-containing cyclic dipeptides. This groundbreaking research not only uncovers the histidine selection mechanism but also opens avenues for creating a diverse library of cyclic dipeptide analogs using various amino acids.

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~3 min • Beginner • English
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