Chemistry

Active coacervate droplets as a model for membraneless organelles and protocells

C. Donau, F. Späth, et al.

Explore the fascinating world of membraneless organelles in this groundbreaking study by Carsten Donau and colleagues from the Technical University of Munich. Discover how RNA-containing active coacervate droplets mimic biological processes through a fuel-driven reaction cycle, highlighting the dynamic nature of these important cellular structures.

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Playback language: English

Index

Abstract

Membraneless organelles, crucial for various intracellular processes, are active liquid-liquid phase-separated droplets often regulated by ATP-dependent reactions. This study presents a model for membraneless organelles using RNA-containing active coacervate droplets controlled by a fuel-driven reaction cycle. These droplets form in the presence of fuel, decay without it, transiently up-concentrate functional RNA, and fragment during decay, mirroring the behavior of biological membraneless organelles.

Publisher

Nature Communications

Published On

Oct 14, 2020

Authors

Carsten Donau, Fabian Späth, Marilyne Sosson, Brigitte A. K. Kriebisch, Fabian Schnitter, Marta Tena-Solsona, Hyun-Seo Kang, Elia Salibi, Michael Sattler, Hannes Mutschler, Job Boekhoven

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