Modern biological imaging microscopes are often expensive black boxes. UC2 (You. See. Too.) is a low-cost, 3D-printed, open-source, modular microscopy toolbox. The authors demonstrate its versatility by building a brightfield microscope monitoring cell differentiation and a light sheet fluorescence microscope for volumetric observations. The design aims to establish an open standard in optics, facilitating interfacing with various platforms and promoting easy replication and modification.
Publisher
Nature Communications
Published On
Nov 25, 2020
Authors
Benedict Diederich, René Lachmann, Swen Carlstedt, Barbora Marsikova, Haoran Wang, Xavier Uwurukundo, Alexander S. Mosig, Rainer Heintzmann
Tags
microscopy
open-source
3D-printed
cell differentiation
light sheet fluorescence
modular toolbox
optical standards
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