Medicine and Health

A Self-Assembling Mosaic Nanoparticle Vaccine for Broad Coronavirus Immunity

P. Bjorkman

This groundbreaking study by Pamela Bjorkman explores a novel mosaic nanoparticle vaccine, 6RBD-np, designed to deliver six receptor-binding domains from coronaviruses. The research showcases its ability to induce high antibody responses and complete protection against SARS-CoV-2 variants, paving the way for a potential broad-spectrum coronavirus vaccine.

00:00

Playback language: English

Index

Abstract

The study introduces a novel mosaic nanoparticle vaccine (6RBD-np) utilizing a self-assembling heterotrimeric proliferating cell nuclear antigen (PCNA) scaffold to deliver six receptor-binding domains (RBDs) from α- and β-coronaviruses. This approach addresses limitations of existing mosaic nanoparticle platforms by ensuring uniform antigen distribution. In mice, 6RBD-np elicited high antibody titers against multiple coronaviruses and conferred complete protection against SARS-CoV-2 WT and Delta variants, demonstrating its potential as a broad-spectrum coronavirus vaccine.

Publisher

PNAS

Published On

Jan 01, 2023

Authors

Pamela Bjorkman

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

Self-assembling nanoparticle engineered from the ferritinophagy complex as a rabies virus vaccine candidate

D. Fu, W. Wang, et al.

Medicine and Health

A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity

K. Das, E. Belnoue, et al.

Medicine and Health

Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants

J. Logue, R. M. Johnson, et al.

Medicine and Health

A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

P. A. Weidenbacher, M. Sanyal, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny