A Self-Assembling Mosaic Nanoparticle Vaccine for Broad | ResearchBunny

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Abstract

The study introduces a novel mosaic nanoparticle vaccine (6RBD-np) utilizing a self-assembling heterotrimeric proliferating cell nuclear antigen (PCNA) scaffold to deliver six receptor-binding domains (RBDs) from α- and β-coronaviruses. This approach addresses limitations of existing mosaic nanoparticle platforms by ensuring uniform antigen distribution. In mice, 6RBD-np elicited high antibody titers against multiple coronaviruses and conferred complete protection against SARS-CoV-2 WT and Delta variants, demonstrating its potential as a broad-spectrum coronavirus vaccine.

Publisher

PNAS

Published On

Jan 01, 2023

Authors

Pamela Bjorkman

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