Biology

A partially self-regenerating synthetic cell

B. Lavickova, N. Laohakunakorn, et al.

Discover groundbreaking advancements in synthetic biology with Barbora Lavickova, Nadanai Laohakunakorn, and Sebastian J. Maerkl’s research on partial molecular self-regeneration in synthetic cells. This study reveals how a minimal transcription-translation system can recreate essential proteins from DNA, sustaining activity for over a day and laying the groundwork for self-replicating cells.

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Abstract

This paper demonstrates partial molecular self-regeneration in a synthetic cell. A minimal transcription-translation system within microfluidic reactors regenerates essential protein components from DNA templates, sustaining synthesis activity for over a day. Optimizing resource allocation and minimizing resource competition are crucial for robust function. The study achieves simultaneous regeneration of multiple proteins by determining required DNA ratios, providing a framework for developing a self-replicating synthetic cell.

Publisher

Nature Communications

Published On

Dec 11, 2020

Authors

Barbora Lavickova, Nadanai Laohakunakorn, Sebastian J. Maerkl

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