This paper demonstrates partial molecular self-regeneration in a synthetic cell. A minimal transcription-translation system within microfluidic reactors regenerates essential protein components from DNA templates, sustaining synthesis activity for over a day. Optimizing resource allocation and minimizing resource competition are crucial for robust function. The study achieves simultaneous regeneration of multiple proteins by determining required DNA ratios, providing a framework for developing a self-replicating synthetic cell.
Publisher
Nature Communications
Published On
Dec 11, 2020
Authors
Barbora Lavickova, Nadanai Laohakunakorn, Sebastian J. Maerkl
Tags
synthetic biology
molecular self-regeneration
protein synthesis
DNA templates
transcription-translation system
microfluidic reactors
self-replicating cells
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