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A new microchannel capillary flow assay (MCFA) platform with lyophilized chemiluminescence reagents for a smartphone-based POCT detecting malaria

Engineering and Technology

A new microchannel capillary flow assay (MCFA) platform with lyophilized chemiluminescence reagents for a smartphone-based POCT detecting malaria

S. Ghosh, K. Aggarwal, et al.

Discover the innovative microchannel capillary flow assay (MCFA) platform, designed for cost-effective and portable chemiluminescence-based ELISA with a remarkable limit of detection of 8 ng/mL for the malaria biomarker PfHRP2. This groundbreaking research, conducted by Sthitodhi Ghosh, Kashish Aggarwal, Vinitha T. U, Thinh Nguyen, Jungyoup Han, and Chong H. Ahn, showcases a smartphone-based solution that easily adapts to other biomarkers.

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Playback language: English
Abstract
This work reports the development of a new microchannel capillary flow assay (MCFA) platform for chemiluminescence-based ELISA using lyophilized reagents. The MCFA platform, utilizing passive flow control and a smartphone-based optical detector connected via USB-OTG, achieves a limit of detection (LOD) of 8 ng/mL for PfHRP2, a malaria biomarker. The system is cost-effective, portable, and easily adaptable for other biomarkers.
Publisher
Microsystems & Nanoengineering
Published On
Jan 01, 2020
Authors
Sthitodhi Ghosh, Kashish Aggarwal, Vinitha T. U, Thinh Nguyen, Jungyoup Han, Chong H. Ahn
Tags
microchannel
capillary flow
chemiluminescence
ELISA
PfHRP2
biomarkers
smartphone detection

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