A genetically encoded tool for reconstituting synthetic

Index

Abstract

This paper introduces HySyn, a novel system for creating or modifying synaptic relationships in vivo. HySyn uses a Hydra-derived neuropeptide and its receptor to create de novo neuromodulatory transmission. The researchers demonstrate HySyn's functionality in mammalian neuronal tissue culture and *C. elegans*, showing its ability to functionally rewire behavioral circuits. HySyn can be integrated with existing tools to probe synaptic transmission, dissect neuropeptide signaling, or modulate specific circuits and behaviors.

Publisher

Nature Communications

Published On

Aug 09, 2021

Authors

Josh D Hawk, Elias M Wisdom, Titas Sengupta, Zane D Kashlan, Daniel A Colón-Ramos

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