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A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo

Biology

A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo

J. D. Hawk, E. M. Wisdom, et al.

Discover the groundbreaking HySyn system developed by researchers Josh D Hawk, Elias M Wisdom, Titas Sengupta, Zane D Kashlan, and Daniel A Colón-Ramos. This innovative approach enables the manipulation of synaptic relationships in vivo, effectively rewiring behavioral circuits in mammalian culture and *C. elegans*. Delve into the potential of HySyn to enhance our understanding of synaptic transmission and neuropeptide signaling.

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Playback language: English
Abstract
This paper introduces HySyn, a novel system for creating or modifying synaptic relationships in vivo. HySyn uses a Hydra-derived neuropeptide and its receptor to create de novo neuromodulatory transmission. The researchers demonstrate HySyn's functionality in mammalian neuronal tissue culture and *C. elegans*, showing its ability to functionally rewire behavioral circuits. HySyn can be integrated with existing tools to probe synaptic transmission, dissect neuropeptide signaling, or modulate specific circuits and behaviors.
Publisher
Nature Communications
Published On
Aug 09, 2021
Authors
Josh D Hawk, Elias M Wisdom, Titas Sengupta, Zane D Kashlan, Daniel A Colón-Ramos
Tags
HySyn
synaptic relationships
neuromodulation
neuropeptide signaling
behavioral circuits
C. elegans
neuroscience

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