A general strategy to develop fluorogenic polymethine dyes for | ResearchBunny

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Abstract

This paper presents a general strategy for transforming polymethine compounds into fluorogenic dyes using an intramolecular ring-closure approach. The authors demonstrate the creation of spontaneously blinking and no-wash, turn-on polymethine dyes with emissions across the visible and near-infrared spectrum. These probes are compatible with self-labeling proteins and small-molecule targeting ligands, enabling multicolor and fluorescence lifetime multiplexing imaging.

Publisher

Nature Chemistry

Published On

Nov 27, 2023

Authors

Annabell Martin, Pablo Rivera-Fuentes

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