This work details the development of a high-performance electrochemical biosensor for cancer detection. A novel mesoporous 2D N, B, and P codoped carbon network (NBP-CNW) arranged into high-order 3D nanotube arrays (NTAs) is synthesized and wrapped onto a flexible carbon fiber microelectrode. The resulting microelectrode exhibits enhanced electrocatalytic activity and durability due to its high surface area, abundant active sites, and efficient charge transport. This microelectrode effectively senses H2O2, a cancer biomarker, and is integrated into a microfluidic chip for real-time monitoring of H2O2 secreted by various cancer cells, both with and without radiotherapy. Furthermore, it's integrated into an implantable probe for in situ cancer tissue detection in surgically resected human specimens. This technology offers a promising approach for improved cancer diagnosis and treatment efficacy assessment.

Yimin Sun, Xulin Dong, Hu He, Yan Zhang, Kai Chi, Yun Xu, Muhammad Asif, Xuan Yang, Wenshan He, Kín Liao, Fei Xiao