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TrkB phosphorylation in serum extracellular vesicles correlates with cognitive function enhanced by ergothioneine in humans

Medicine and Health

TrkB phosphorylation in serum extracellular vesicles correlates with cognitive function enhanced by ergothioneine in humans

T. Ishimoto, R. Yamashita, et al.

Discover how oral ergothioneine (ERGO) can boost cognitive function and its remarkable impact on cognitive enhancement in both mice and humans. This groundbreaking research by Takahiro Ishimoto, Reiya Yamashita, Ruri Matsumoto, Satoshi Matsumoto, Yusuke Matsuo, Shunsuke Nakao, Yusuke Masuo, Makoto Suzuki, and Yukio Kato reveals the connection between ERGO deficiency and cognitive impairment, highlighting TrkB's involvement in recovery.

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Playback language: English
Abstract
Oral ergothioneine (ERGO) enhances cognitive function, but the effects of ERGO deficiency and underlying mechanisms are unclear. This study found that ERGO-deficient mice exhibited impaired cognitive function and hippocampal neurogenesis, reversed by ERGO supplementation. This recovery was blocked by TrkB inhibition, suggesting TrkB's involvement. In humans, ERGO treatment increased serum EV-derived phosphorylated TrkB, correlating with serum ERGO levels and cognitive scores. Therefore, TrkB phosphorylation is involved in ERGO-induced cognitive enhancement in both mice and humans.
Publisher
npj Science of Food
Published On
Feb 06, 2024
Authors
Takahiro Ishimoto, Reiya Yamashita, Ruri Matsumoto, Satoshi Matsumoto, Yusuke Matsuo, Shunsuke Nakao, Yusuke Masuo, Makoto Suzuki, Yukio Kato
Tags
ergothioneine
cognitive function
neurogenesis
TrkB phosphorylation
mouse model
human study
serum levels

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