Medicine and Health

Transcriptional dissection of symptomatic profiles across the brain of men and women with depression

S. Mansouri, A. M. Pessoni, et al.

This study, conducted by Samaneh Mansouri and colleagues, explores sex-specific gene modules linked to Major Depressive Disorder symptoms across various brain regions. Discover how differential gene expression reveals distinct symptomatic profiles and associations with key neurotransmission pathways.

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Abstract

This study investigated sex-specific gene modules associated with Major Depressive Disorder (MDD) symptoms using differential gene expression and co-expression network analyses in six brain regions. Results revealed varying network homology between sexes, with sex-specific associations between brain structures and MDD symptom expression. Transcriptional signatures linked to pathways like GABAergic and glutamatergic neurotransmission, metabolic processes, and intracellular signal transduction were identified, demonstrating sex-specific associations with distinct symptomatic profiles across brain regions.

Publisher

Nature Communications

Published On

Oct 26, 2023

Authors

Samaneh Mansouri, André M. Pessoni, Arturo Marroquín-Rivera, Eric M. Parise, Carol A. Tamminga, Gustavo Turecki, Eric J. Nestler, Ting-Huei Chen, Benoit Labonté

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