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Total sleep deprivation increases pain sensitivity, impairs conditioned pain modulation and facilitates temporal summation of pain in healthy participants

Medicine and Health

Total sleep deprivation increases pain sensitivity, impairs conditioned pain modulation and facilitates temporal summation of pain in healthy participants

A. T. Staffe, M. W. Bech, et al.

Explore how total sleep deprivation impacts pain sensitivity in this compelling study by Alexander Torp Staffe and colleagues. Discover the surprising connection between sleep and pain mechanisms, revealing critical insights into chronic pain management.

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Playback language: English
Abstract
Chronic pain patients often experience insomnia or sleep impairment, which has been linked to heightened pain sensitivity. This study investigated the effects of total sleep deprivation (TSD) on central pain mechanisms in healthy participants. Twenty-four participants underwent measurements after a night of habitual sleep (baseline) and after 24 hours of TSD. Results showed significant impairment in conditioned pain modulation (CPM), facilitation of temporal summation of pain (TSP), and increased sensitivity to pressure and cold pain after TSD. This suggests TSD impacts descending pain pathways, spinal excitability, and peripheral sensitivity.
Publisher
PLOS ONE
Published On
Dec 04, 2019
Authors
Alexander Torp Staffe, Mathias Winther Bech, Sara Louise Kjær Clemmensen, Henriette Tranberg Nielsen, Dennis Boye Larsen, Kristian Kjær Petersen
Tags
chronic pain
total sleep deprivation
pain sensitivity
conditioned pain modulation
temporal summation of pain
sleep impairment
central pain mechanisms

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