Medicine and Health

Time-of-flight resolved light field fluctuations reveal deep human tissue physiology

O. Kholiqov, W. Zhou, et al.

Discover how a novel interferometric technique enhances diffuse optical flowmetry (DOF) measurements, revealing the intricacies of red blood cell dynamics in deep tissues. This impactful research, conducted by Oybek Kholiqov, Wenjun Zhou, Tingwei Zhang, V.N. Du Le, and Vivek J. Srinivasan, addresses challenges and paves the way for more accurate blood flow assessment in humans.

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Abstract

Diffuse optical flowmetry (DOF) assesses deep tissue red blood cell (RBC) dynamics by measuring coherent fluctuations of multiply scattered near-infrared light intensity. This paper introduces an interferometric technique to improve DOF measurements by adding optical phase and time-of-flight (TOF) dimensions. The technique confirms the Brownian nature of RBC dynamics and illustrates how factors like absorption assumptions, anisotropic RBC scattering, and layered tissues can confound classical DOF. The new method enables accurate and comprehensive assessment of blood flow dynamics in humans.

Publisher

Nature Communications

Published On

Jan 20, 2020

Authors

Oybek Kholiqov, Wenjun Zhou, Tingwei Zhang, V.N. Du Le, Vivek J. Srinivasan

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