Chemistry

Thymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers

J. Zhuang, G. Qi, et al.

Discover how Jiahao Zhuang and colleagues have developed a groundbreaking method to transform Type II photosensitizers into Type I photosensitizers using thymoquinone, enhancing ROS generation and achieving impressive bactericidal activity against *S. aureus*, even in low-oxygen environments.

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Abstract

This paper reports a novel method to convert Type II photosensitizers (PSs) into Type I PSs using thymoquinone (TQ) as an electron transfer mediator. The combination of a Type II PS and carvacrol (CA) significantly enhances Type I ROS generation, specifically superoxide radicals (O2−). CA is converted to TQ by singlet oxygen (¹O2) generated from the PS. TQ then mediates electron transfer from the PS to oxygen, producing O2−. This approach was demonstrated using three classical Type II PSs *in vitro* and *in vivo*, showing significant bactericidal activity against *S. aureus* even under hypoxic conditions.

Publisher

Nature Communications

Published On

Jun 10, 2024

Authors

Jiahao Zhuang, Guobin Qi, Yecheng Feng, Min Wu, Hang Zhang, Dandan Wang, Xianhe Zhang, Kok Chan Chong, Bowen Li, Shitai Liu, Jianwu Tian, Yi Shan, Duo Mao, Bin Liu

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