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Three-year outcomes of post-acute sequelae of COVID-19

Medicine and Health

Three-year outcomes of post-acute sequelae of COVID-19

M. Cai, Y. Xie, et al.

This groundbreaking study reveals the long-term outcomes of post-acute sequelae of COVID-19 among US veterans. Notably, while non-hospitalized individuals may see a decline in PASC risk after the first year, hospitalized patients continue to face significant health challenges. Conducted by Miao Cai, Yan Xie, Eric J. Topol, and Ziyad Al-Aly, this research underscores the ongoing burden of COVID-19.

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Playback language: English
Abstract
This study investigated the three-year outcomes of post-acute sequelae of COVID-19 (PASC) in a large cohort of US veterans. Among non-hospitalized individuals, the increased risk of death resolved after the first year, while the risk of PASC declined but persisted, contributing to 9.6 disability-adjusted life years (DALYs) per 1,000 persons in the third year. Hospitalized individuals showed a persistently elevated risk of death (incidence rate ratio: 1.29) and a substantial residual risk of PASC (90.0 DALYs per 1,000 persons) in the third year. The study highlights the long-term burden of mortality and health loss, particularly among hospitalized COVID-19 patients.
Publisher
Nature Medicine
Published On
Jun 01, 2024
Authors
Miao Cai, Yan Xie, Eric J. Topol, Ziyad Al-Aly
Tags
COVID-19
PASC
US veterans
mortality
long-term health
disability-adjusted life years
hospitalized patients

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