This review describes available 3D structures of the µ opioid receptor in the protein data bank and provides structural insights for the binding of agonists and antagonists to the receptor. Comparative analysis on the atomic details of the binding site in these structures was conducted and distinct binding interactions for agonists, partial agonists, and antagonists were observed. The findings in this article deepen our understanding of the ligand binding activity and shed some light on the development of novel opioid analgesics which may improve the risk benefit balance of existing opioids.
Publisher
International Journal of Molecular Sciences
Published On
Apr 11, 2023
Authors
Zoe Li, Jie Liu, Fan Dong, Nancy Chang, Ruili Huang, Menghang Xia, Tucker A Patterson, Huixiao Hong
Tags
µ opioid receptor
3D structures
agonists
antagonists
ligand binding
opioid analgesics
structural insights
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