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The need for high-resolution gut microbiome characterization to design efficient strategies for sustainable aquaculture production

Veterinary Science

The need for high-resolution gut microbiome characterization to design efficient strategies for sustainable aquaculture production

S. Gupta, A. V. D. León, et al.

This fascinating study delves into the effects of microbiota-directed fibers in Atlantic salmon, uncovering how varying dietary inclusions influence gut microbiome composition. Despite a notable shift at a higher dose, the research reveals minimal impacts on host gene expression and highlights the need for advanced microbiome characterization. Conducted by a diverse team of researchers including Shashank Gupta and Arturo Vera-Ponce de León, this work paves the way for future interventions targeting lactic acid bacteria.

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Playback language: English
Abstract
This study investigated the effects of microbiota-directed fibers (MDFs) – α-mannans and β-mannan – as feed supplements in Atlantic salmon. Multi-omic analysis (16S rRNA gene profiling, metatranscriptomics, targeted metabolomics, and salmon organ transcriptomics) revealed negligible effects on host gene expression, gut microbiome structure, and function at a 0.2% dietary inclusion. A higher dose (4%) of β-mannan significantly shifted microbiome composition but lacked biologically relevant effects on salmon. Only *Burkholderia-Caballeronia-Paraburkholderia* showed consistent abundance shifts. The study highlights the need for high-resolution microbiome characterization for designing effective MDF strategies and identifies potential endogenous lactic acid bacteria as targets for future interventions.
Publisher
Communications Biology
Published On
Oct 25, 2024
Authors
Shashank Gupta, Arturo Vera-Ponce de León, Miyako Kodama, Matthias Hoetzinger, Cecilie G. Clausen, Louisa Pless, Ana R. A. Verissimo, Bruno Stengel, Virginia Calabugi, Renate Kvingedal, Stanko Skugor, Bjørge Westereng, Thomas Nelson Harvey, Anna Nordborg, Stefan Bertilsson, Morten T. Limborg, Turid Mørkøre, Simen R. Sandve, Phillip B. Pope, Torgeir R. Hvidsten, Sabina Leanti La Rosa
Tags
microbiota-directed fibers
Atlantic salmon
gut microbiome
β-mannan
multi-omic analysis
lactic acid bacteria
feed supplements

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