Temporal dynamics of the multi-omic response to endurance exercise training

Regular exercise improves health and prevents disease, but the underlying mechanisms are unclear. This study used multi-omic profiling across various tissues in male and female rats undergoing endurance training to understand the molecular adaptations. The study identified thousands of molecular alterations, revealing insights into immune, metabolic, stress response, and mitochondrial pathways, with implications for human health conditions.

David Amar, Nicole R. Gay, Pierre M. Jean-Beltran, Dam Bae, Surendra Dasari, Courtney Dennis, Charles R. Evans, David A. Gaul, Olga Ilkayeva, Anna A. Ivanova, Maureen T. Kachman, Ian R. Lanza, Ana C. Lira, Michael J. Muehlbauer, Venugopalan D. Nair, Paul D. Piehowski, Jessica L. Rooney, Kevin S. Smith, Cynthia L. Stowe, Bingqing Zhao, Natalie M. Clark, David Jimenez-Morales, Malene E. Lindholm, Gina M. Many, James A. Sanford, Gregory R. Smith, Nikolai G. Vetr, Tiantian Zhang, Jose J. Almagro Armenteros, Julian Avila-Pacheco, Nasim Bararpour, Yongchao Ge, Zhenxin Hou, Shruti Marwaha, David M. Presby, Archana Natarajan Raja, Evan M. Savage, Alec Steep, Yifei Sun, Si Wu, Jimmy Zhen, Sue C. Bodine, Karyn A. Esser, Laurie J. Goodyear, Simon Schenk, Stephen B. Montgomery, Facundo M. Fernández, Robert E. Gerszten, William E. Kraus, Jun Z. Li, Michael E. Miller, K. Sreekumaran Nair, Christopher Newgard, Eric A. Ortlund, Wei-Jun Qian, Russell Tracy, Martin J. Walsh, Matthew T. Wheeler