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TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of *Btn1a1* and *Xdh*

Medicine and Health

TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of *Btn1a1* and *Xdh*

L. Zhao, H. Ke, et al.

This groundbreaking study reveals the pivotal role of TDP-43 in milk lipid secretion, with researchers demonstrating that its absence in mice leads to severe lactation failure. Human milk analysis corroborated a positive correlation between TDP-43 levels and milk output, indicating its potential as a therapeutic target for those struggling with lactation insufficiency. This essential research was conducted by Limin Zhao, Hao Ke, Haibo Xu, Guo-Dong Wang, Honglei Zhang, Li Zou, Shu Xiang, Mengyuan Li, Li Peng, Mingfang Zhou, Lingling Li, Lei Ao, Qin Yang, Che-Kun James Shen, Ping Yi, Lu Wang, and Baowei Jiao.

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Playback language: English
Abstract
This study investigates the role of TDP-43, an RNA-binding protein, in milk lipid secretion. Researchers found that TDP-43 underwent positive selection in the mammalian lineage and that its loss (*Tardbp* gene knockout) in mice resulted in lactation failure and pup starvation. Mechanistically, TDP-43 regulates the mRNA stability of *Btn1a1* and *Xdh*, genes essential for lipid droplet secretion. Human milk samples showed a positive correlation between TDP-43 expression and milk output, highlighting its crucial role in lactation and suggesting potential therapeutic targets for lactation insufficiency.
Publisher
NATURE COMMUNICATIONS
Published On
Jan 17, 2020
Authors
Limin Zhao, Hao Ke, Haibo Xu, Guo-Dong Wang, Honglei Zhang, Li Zou, Shu Xiang, Mengyuan Li, Li Peng, Mingfang Zhou, Lingling Li, Lei Ao, Qin Yang, Che-Kun James Shen, Ping Yi, Lu Wang, Baowei Jiao
Tags
TDP-43
milk lipid secretion
lactation
mice
RNA-binding protein
therapeutic targets
mRNA stability

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