Medicine and Health

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

G. Collaborative

This extensive international study by the GlobalSurg Collaborative reveals alarming insights into the global burden of surgical site infections (SSI) after gastrointestinal surgery. With over 12,500 patients analyzed across 66 countries, the findings highlight a worrisome trend: a significantly higher incidence of SSI in low-HDI countries. This urgent research underscores the need for effective interventions to combat this preventable complication.

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Abstract

This international, prospective, multicentre cohort study investigated the global burden of surgical site infection (SSI) after gastrointestinal surgery. 12,539 patients from 343 hospitals in 66 countries were included, stratified into high, middle, and low Human Development Index (HDI) groups. 12.3% of patients developed SSI within 30 days. SSI incidence varied significantly across HDI groups (high: 9.4%, middle: 14.0%, low: 23.2%). After risk adjustment, patients in low-HDI countries had the highest risk of SSI (adjusted odds ratio 1.60). Antibiotic-resistant infections were more prevalent in low-HDI countries (35.9%). The study highlights the disproportionate burden of SSI in low-HDI countries and the need for urgent, pragmatic, randomized trials to address this preventable complication.

Publisher

The Lancet Infectious Diseases

Published On

May 27, 2018

Authors

GlobalSurg Collaborative

DOI

https://doi.org/10.1016/s1473-3099(18)30101-4

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