Medicine and Health

sGC stimulation lowers elevated blood pressure in a new canine model of resistant hypertension

J. Vogel, P. Boehme, et al.

This groundbreaking study reveals a new canine model for therapy-resistant hypertension, demonstrating the remarkable efficacy of the soluble guanylyl cyclase stimulator, BAY 41-2272. Conducted by a team of researchers, including Julia Vogel and Philip Boehme, the findings suggest promising treatment options for this challenging medical condition.

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Abstract

Therapy-resistant hypertension is a serious medical problem. This study established a new canine model of resistant hypertension by combining unilateral renal wrapping with contralateral renal artery occlusion. The effects of the soluble guanylyl cyclase (sGC) stimulator BAY 41-2272 were investigated. Standard-of-care antihypertensives had only a slight effect on blood pressure, while BAY 41-2272 produced a dose-dependent reduction, both as a standalone therapy and in combination with standard treatments. The results suggest sGC stimulators may be an effective treatment option for resistant hypertension.

Publisher

Springer Nature

Published On

Sep 22, 2021

Authors

Julia Vogel, Philip Boehme, Susanne Homann, Mario Boehm, Katharina Andrea Schütt, Katharina Boden, Jakob Balitzki, Jörg Hüser, Wilfried Dinh, Hubert Truebel, Peter Sandner, Thomas Mondritzki

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