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Abstract
Therapy-resistant hypertension is a serious medical problem. This study established a new canine model of resistant hypertension by combining unilateral renal wrapping with contralateral renal artery occlusion. The effects of the soluble guanylyl cyclase (sGC) stimulator BAY 41-2272 were investigated. Standard-of-care antihypertensives had only a slight effect on blood pressure, while BAY 41-2272 produced a dose-dependent reduction, both as a standalone therapy and in combination with standard treatments. The results suggest sGC stimulators may be an effective treatment option for resistant hypertension.
Publisher
Springer Nature
Published On
Sep 22, 2021
Authors
Julia Vogel, Philip Boehme, Susanne Homann, Mario Boehm, Katharina Andrea Schütt, Katharina Boden, Jakob Balitzki, Jörg Hüser, Wilfried Dinh, Hubert Truebel, Peter Sandner, Thomas Mondritzki
Tags
resistant hypertension
sGC stimulator
BAY 41-2272
canine model
antihypertensives
blood pressure
therapy-resistant

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