Medicine and Health

Ripple-locked coactivity of stimulus-specific neurons and human associative memory

L. Kunz, B. P. Staresina, et al.

Dive into the fascinating world of associative memory with cutting-edge research conducted by Lukas Kunz and colleagues. This study reveals how object-specific and place-specific neurons work together in the medial temporal lobe, showcasing the intricate dynamics of neuronal activations during memory tasks. Uncover the flexibility of neuron-ripple interactions as demonstrated through single-neuron recordings from epilepsy patients!

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Playback language: English

Index

Abstract

Associative memory, crucial for learning relations between stimuli, involves the medial temporal lobe (MTL). Using single-neuron recordings from epilepsy patients performing an associative object-location memory task, researchers identified object-specific and place-specific neurons. During encoding and retrieval, these neurons activated together during hippocampal ripples, a phenomenon that strengthened with learning. The ripple-locked timing shifted between encoding and retrieval, suggesting MTL neuron-ripple interaction flexibility.

Publisher

Nature Neuroscience

Published On

Mar 01, 2024

Authors

Lukas Kunz, Bernhard P. Staresina, Peter C. Reinacher, Armin Brandt, Tim A. Guth, Andreas Schulze-Bonhage, Joshua Jacobs

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