This study investigated differences in blood pressure (BP) parameters between beat-to-beat PTT-estimated BP (eBPBTB) and intermittent PTT-estimated BP (eBPINT) in patients with suspected sleep-disordered breathing (SDB). In 330 patients, nighttime PTT-estimated BP was continuously recorded. Average systolic eBPBTB, maximum systolic and diastolic eBPBTB, and BP variability indices (standard deviation and coefficient of variation) were higher with eBPBTB than eBPINT (all P<0.05). Bland-Altman analysis showed close agreement for average systolic BP and BP variability, but disagreement for minimum and maximum BP values, particularly in patients with high systolic BP. Systolic BP variability increased with oxygen desaturation index (ODI) in both eBPBTB and eBPINT, with no difference in this tendency between methods. The difference between eBPBTB and eBPINT was minimal, with disagreements mainly concerning minimum and maximum BP values but agreement on BP variability indices.