Medicine and Health

Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts

C. R. Shaler, A. A. Parco, et al.

This groundbreaking research reveals how psychological stress can disrupt gut immunity and foster the growth of harmful bacteria associated with Crohn's disease. Conducted by a team of experts including Christopher R. Shaler and Alexandra A. Parco, the study uncovers the potential of immunomodulation to restore balance and combat dysbiosis in the gut.

00:00

Playback language: English

Index

Abstract

Crohn's disease (CD) is an inflammatory bowel disease linked to microbial and environmental factors, including psychological stress. This study demonstrates that stress-exposed mice exhibit ileal dysbiosis, dominated by Enterobacteriaceae expansion. Stress-induced glucocorticoids promote apoptosis of IL-22-producing CD45+CD90+ cells, crucial for ileal mucosal barrier integrity. Blocking glucocorticoid signaling or administering recombinant IL-22 restores mucosal immunity, prevents dysbiosis, and inhibits AIEC expansion. This suggests that psychological stress impairs IL-22-mediated gut immunity, creating a niche for Crohn's disease-associated pathobionts. Immunomodulation can counteract stress's negative effects on gut immunity and dysbiosis.

Publisher

Nature Communications

Published On

Nov 18, 2021

Authors

Christopher R. Shaler, Alexandra A. Parco, Wael Elhenawy, Jasmeen Dourka, Jennifer Jury, Elena F. Verdu, Brian K. Coombes

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice

A. S. Ashhurst, M. D. Johansen, et al.

Psychology

Psychological resilience mediates the protective role of default-mode network functional connectivity against COVID-19 vicarious traumatization

X. Liu, Y. Zhao, et al.

Biology

Protective roles and protective mechanisms of neutralizing antibodies against SARS-CoV-2 infection and their potential clinical implications

E. C. Abebe and T. A. Dejenie

Psychology

Psychological health, sleep quality, and coping styles to stress facing the COVID-19 in Wuhan, China

W. Fu, C. Wang, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny