Medicine and Health

Profiling the heterogeneity of colorectal cancer consensus molecular subtypes using spatial transcriptomics

A. Valdeolivas, B. Amberg, et al.

This groundbreaking study employs Spatial Transcriptomics and single-cell RNA sequencing to explore the spatial distribution of colorectal cancer subtypes, revealing valuable insights into tumor-stroma interactions. Conducted by a talented team including Alberto Valdeolivas and Bettina Amberg, this research paves the way for advancing personalized therapies in colorectal cancer treatment.

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Abstract

This study used Spatial Transcriptomics (ST) and single-cell RNA sequencing (scRNA-seq) to analyze the spatial distribution of colorectal cancer (CRC) consensus molecular subtypes (CMS) and their microenvironment. The researchers mapped intratumoral heterogeneity of CMS, identified cell communication events at the tumor-stroma interface of CMS2 carcinomas, and demonstrated the potential of ST to advance personalized therapy for CRC.

Publisher

npj Precision Oncology

Published On

Jan 10, 2024

Authors

Alberto Valdeolivas, Bettina Amberg, Nicolas Giroud, Marion Richardson, Eric J. C. Gálvez, Solveig Badillo, Alice Julien-Laferrière, Demeter Túrós, Lena Voith von Voithenberg, Isabelle Wells, Benedek Pesti, Amy A. Lo, Emilio Yángüez, Meghna Das Thakur, Michael Bscheider, Marc Sultan, Nadine Kumpesa, Björn Jacobsen, Tobias Bergauer, Julio Saez-Rodriguez, Sven Rottenberg, Petra C. Schwalie, Kerstin Hahn

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