Psychology

Plasma proteomics discovery of mental health risk biomarkers in adolescents

I. D. S. Maciel, A. Piironen, et al.

Unlock the mysteries of adolescent mental health! This groundbreaking study reveals potential plasma protein biomarkers linked to mental health issues in teenagers. Uncover how the research conducted by Izaque de Sousa Maciel and colleagues could pave the way for early identification of at-risk youth.

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Abstract

This study aimed to discover plasma protein-based susceptibility biomarkers in adolescents (11–16 years) at risk of mental health issues, using self-reported Strengths and Difficulties Questionnaire (SDQ) scores and plasma proteomic data from the Spanish WALNUTS cohort. Bioinformatic analyses of 58 proteins significantly associated with SDQ scores revealed enriched pathways related to immune responses, blood coagulation, neurogenesis, and neuronal degeneration. The study suggests potential novel biomarkers for early identification of adolescents at risk of mental health problems.

Publisher

Nature Mental Health

Published On

Jul 31, 2023

Authors

Izaque de Sousa Maciel, Aino-Kaisa Piironen, Alexey M. Afonin, Mariia Ivanova, Arto Alatalo, Kaustubh Kishor Jadhav, Jordi Julvez, Maria Foraster, Irene van Kamp, Katja M. Kanninen

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