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Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer

Medicine and Health

Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer

Z. Ding, Q. Li, et al.

This pilot study explores the promising safety and efficacy of the personalized neoantigen peptide-pulsed autologous dendritic cell vaccine (Neo-DCVac) for advanced lung cancer. With a well-tolerated profile and a notable objective response rate of 25%, this research could redefine treatment options for patients facing this challenging disease. Conducted by a dedicated team of researchers.

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Playback language: English
Abstract
This pilot study investigated the safety and efficacy of a personalized neoantigen peptide-pulsed autologous DC vaccine (Neo-DCVac) in treating advanced lung cancer. Twelve heavily treated metastatic lung cancer patients received a median of 5 doses of Neo-DCVac, each containing 12-30 peptide-based neoantigens selected via whole-exome and RNA sequencing. The vaccine was well-tolerated with only grade 1-2 adverse events. The objective response rate was 25%, disease control rate 75%, median progression-free survival 5.5 months, and median overall survival 7.9 months. The study suggests Neo-DCVac as a feasible and potentially effective treatment option for advanced lung cancer.
Publisher
Signal Transduction and Targeted Therapy
Published On
Jan 20, 2021
Authors
Zhenyu Ding, Qing Li, Rui Zhang, Li Xie, Yang Shu, Song Gao, Peipei Wang, Xiaoqing Su, Yun Qin, Yuelan Wang, Juemin Fang, Zhongzheng Zhu, Xuyang Xia, Guochao Wei, Hui Wang, Hong Qian, Xianling Guo, Zhibo Gao, Yu Wang, Yuquan Wei, Qing Xu, Heng Xu, Li Yang
Tags
neoantigen
dendritic cell vaccine
lung cancer
safety
efficacy
treatment
personalized medicine
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