Psychology

Persistence of amygdala hyperactivity to subliminal negative emotion processing in the long-term course of depression

M. Klug, V. Enneking, et al.

This innovative study explores the enduring brain functions associated with automatic emotion processing in people experiencing long-term depression. Conducted by Melissa Klug and colleagues, it reveals persistent amygdala hyperactivity in response to sad stimuli among individuals with acute major depressive disorder, highlighting a potential trait marker for depression.

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Abstract

This prospective case-control study investigated brain functional correlates of automatic emotion processing in the long-term course of depression. 57 patients with acute major depressive disorder (MDD) and 37 healthy controls (HC) underwent fMRI at baseline and after 2 years, performing an affective priming task with subliminal sad, happy, and neutral face stimuli. At baseline, MDD patients showed amygdala hyperactivity to sad primes. This hyperactivity persisted after 2 years in both relapse and no-relapse subgroups, suggesting that amygdala hyperactivity during automatic negative stimuli processing is a persistent trait, rather than a state, marker of depression.

Publisher

Molecular Psychiatry

Published On

Jan 26, 2024

Authors

Melissa Klug, Verena Enneking, Tiana Borgers, Charlotte M. Jacobs, Katharina Dohm, Anna Kraus, Dominik Grotegerd, Nils Opel, Jonathan Repple, Thomas Suslow, Susanne Meinert, Hannah Lemke, Elisabeth J. Leehr, Jochen Bauer, Udo Dannlowski, Ronny Redlich

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