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Abstract
The evolutionarily conserved Par3/Par6/aPKC complex regulates the polarity establishment of diverse cell types. This study shows that the Par complex exhibits cell cycle-dependent condensation in *Drosophila* neuroblasts, driven by liquid-liquid phase separation (LLPS). Par3's open conformation undergoes autonomous phase separation due to NTD-mediated oligomerization. Par6 enhances Par3 phase separation, and aPKC is concentrated in the condensates but can disperse them upon activation via Par3 phosphorylation. Perturbations of Par3/Par6 phase separation impair apical-basal polarity and lineage development, suggesting LLPS as a common mechanism for cortical condensation of cell polarity complexes.
Publisher
Nature Communications
Published On
May 08, 2020
Authors
Ziheng Liu, Ying Yang, Aihong Gu, Jiawen Xu, Ying Mao, Haojie Lu, Weiguo Hu, Qun-Ying Lei, Zhouhua Li, Mingjie Zhang, Yu Cai, Wenyu Wen
Tags
cell polarity
liquid-liquid phase separation
Drosophila
Par3
Par6
aPKC
neuroblasts
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