This study investigates the influence of home literacy practices on children's neural responses to printed words. Parents of French children (n=66) reported the frequency of home literacy practices, and a subset (n=44) underwent fMRI during a word adaptation task. More frequent home literacy practices correlated with enhanced word adaptation in the left posterior inferior frontal sulcus (pIFS). This relationship was mediated by vocabulary skills. These findings suggest that home literacy experiences improve vocabulary, influencing neural mechanisms supporting word-level reading.